教育、工作背景：
2007-2011南京中医药大学 药学 本科
2017-2021南京工业大学 制药工程与技术博士
2018-2021美国加州大学洛杉矶分校制药工程与技术 博士
2022-现在中国药科大学 化学学院特聘副研究员
简介：
长期深耕以治疗性核酸、蛋白及多肽为核心的生物大分子药物领域，聚焦药物构建、制剂开发与成药性系统优化，贯通分子设计、递送系统研发至体内外药效评价的完整“做药链条”。成功构建多款基于响应性材料的长效靶向递送平台，在肿瘤与心脑血管疾病治疗领域展现出良好的临床转化前景。近年来以第一或通讯作者在Advanced Materials、JACS、Small、Bioactive Materials等国际高水平期刊发表SCI论文10余篇，授权中国发明专利3项，申请专利10余件。现任Exploration、Journal of Biological Methods、Advanced Interventional Materials等期刊（青年）编委，江苏省侨联青年委员。
研究方向：
纳米药物、药物递送、核酸、蛋白、多肽、生物材料、高端制剂、人工智能辅助药物设计、肿瘤微环境调控、心脑血管疾病治疗、抗炎、抗衰。
合作老师：
王越 教授
代表性文章：
Lou, F.; Wei, Q.; Yin, Y.; Liu, S.; He, Z.; Tan, S.; Gao, J.; Dong, Z.; Xu, Y.; Li, Z.; Wang, Y.; Yan, R. CD44-Targeted Gold-Nanorod-Based Nano-adjuvant Combining Mild Photothermal Therapy and Immune Activation for Triple-Negative Breast Cancer Therapy. ACS Appl. Nano Mater. 2025, 8 (32), 16040–16052.
Yan, R.; Li, Y.; Gu, N. From Rational Design to Druggability Optimization: A Review of Iron-based Nanozymes for Biomedical Applications. ACS Appl. Nano Mater. 2025, 8 (31), 15419–15440.
Chen, Y.; Chen, Q.; Ma, Y.; Su, X.; Zhang, C.; Li, K.; Liang, M.; Sun, M.; Zhang, L.; Kuang, X.; Zhang, T.; Zhang, J.; Yan, R.; Ju, S.; Fan, W. Cathepsin B-Ignited Nanorocket To Blast Tumor Lysosomes for TLR-Fortified Lysosomal Immunotherapy with Dual-Switchable Fluorescence/Magnetic Resonance Imaging. J. Am. Chem. Soc. 2025, 147 (28), 24884–24899.
Qin, X.; Yuan, H.; Zhang, M.; Liu, C.; Yan, R.; Song, H.; Dai, Q. Controlled Platelet-Derived Growth Factor Delivery by Hyaluronic Acid Hydrogels with Tunable Crosslinking for Accelerated Chronic Wound Healing. Int. J. Biol. Macromol. 2025, 304 (1), 140710.
Zhang, T.; Tang, D.; Wu, P.; Jiang, S.; Zhang, Y.; Naeem, A.; Li, Y.; Li, C.; Hu, B.; Guo, S.; Sun, C.; Xiao, H.; Yan, R.; Weng, Y.; Huang, Y. NIR-II Photo-accelerated Polymer Nanoparticles Boost Tumor Immunotherapy via PD-L1 Silencing and Immunogenic Cell Death. Bioact. Mater. 2025, 46, 285–300.
Liu, M.; Sun, Y.; Wei, Q.; Zhang, A.; Wang, S.; Wang, D.; Dong, Z.; Ma, X.; Yan, R.; Wang, Y. 4T1 Cell Membrane Biomimetic Nanovehicle for Enhanced Breast Cancer Treatment. ACS Med. Chem. Lett. 2025, 16 (1), 51–58.
Zhang, J.; Zhang, A.; Liu, S.; Dong, Z.; Zhao, J.; Sun, Y.; Wei, Q.; Wang, D.; Wang, S.; Yu, A.; Li, Z.; Yan, R.; Wang, Y. Nanosized Porphyrin-Containing Covalent Organic Polymer to Enhance Ferroptosis in Photodynamic Treatment of Tumor Cells via Glutathione Depletion. Bioconjug. Chem. 2024, 35 (9), 1450–1458.
Cai, X.; Liu, W.; Zhang, J.; Li, Z.; Liu, M.; Hu, S.; Luo, J.; Peng, K.; Ye, B.; Wang, Y.; Yan, R. Study of Iron Complex Photosensitizer with Hollow Double‐Shell Nano Structure Used to Enhance Ferroptosis and Photodynamic Therapy. Small2024, 20 (30), 2309086.
Zhang, J.; Yin, Y.; Hu, S.; Wang, G.; Tong, Y.; Zen, M.; Liang, Z.; Li, M.; Yan, R.; Wang, Y. Green synthesis of anti-bacterial nano silver by polysaccharide from bletilla striata. Inorganics 2023, 11 (1), 40.
Yan, R.; Ren, J.; Wen, J.; Cao, Z.; Wu, D.; Qin, M.; Xu, D.; Castillo, R.; Li, F.; Wang, F.; et al. Enzyme therapeutic for ischemia and reperfusion injury in organ transplantation. Adv. Mater. 2022, 34 (1), 2105670.
Li, F.; Yan, R.; Wu, J.; Han, Z.; Qin, M.; Liu, C.; Lu, Y. An Antioxidant Enzyme Therapeutic for Sepsis. Front. Bioeng. Biotechnol. 2021, 9, 800684.
Wu, D.; Yang, Y.; Xu, P.; Xu, D.; Liu, Y.; Castillo, R.; Yan, R.; Ren, J.; Zhou, G.; Liu, C.; et al. Real‐Time Quantification of Cell Internalization Kinetics by Functionalized Bioluminescent Nanoprobes. Adv. Mater. 2019, 31 (39), 1902469.