
教育、工作背景:
1999-2003 南京大学 生物技术 本科
2003-2008 香港科技大学 生物工程 博士
2009-2015 新加坡科技局A*STAR 博士后
2015-2017 新加坡南洋理工大学 博士后
2017-2017 香港纳米及先进材料研究院 高级工程师
2017-2022 中国药科大学 理学院 副研究员
2022-现在 中国药科大学 理学院 副教授
简介:
课题组主要研究方向为多肽生物材料的设计和生物医药应用。迄今共发表SCI论文60余篇,国际发明专利5项,H-index为30,同行引用5300余次。主持和参与国家自然科学基金面上项目两项。近三年在AdvancedDrug Delivery Reviews,AdvancedFunctional Materials,ActaBiomaterialia 和Analytical Chemistry 等国际期刊发表论文20余篇。
研究方向:
多肽自组装、水凝胶、微针、药物递送和诊疗一体化
合作老师:
钟文英 教授
代表性文章:
1.Pan, X.; Kang, Y.; Zhou, S.; Zhang, T.; Zheng, Y.; Jin, Q.; Zhong,W.; Xu, K. A Multifunctional Rocket‐Like Microneedle Systemwith Thrusters for Self‐Promoted Deep Drug Penetration andCombination Treatment in Melanoma. Advanced Functional Materials2024, 34, 2405696.
2.Zhang, T.; Luo, X.; Xu, K.; Zhong, W. Peptide-ContainingNanoformulations: Skin Barrier Penetration and Activity Contribution.Advanced Drug Delivery Reviews 2023, 203, 115139.
3.Chen, X.; Liu, Z.; Lei, W.; Su, M.; Zhang, T.; Wu, X.; Zhong, W.; XuK. A Dual-Channel NIR Fluorescent Probe for Self-CalibratedRatiometric Imaging and In Vivo Discrimination of Malignant Tumorsvia Alkaline Phosphatase Activity. Analytical Chemistry 2026,98, 16163-16173.
4.Zhang, T.; Chen, X.; Hao, S.; Qin, Y.; Luo, Q.; Yan, R.; Zhong, W.;Xu, K. Silent-to-Bright CTCs-Hitchhiking Peptide Nanoprobe forActivatable NIR Imaging of Lung Metastasis in Mice. AnalyticalChemistry 2026, 98, 13790-13802.
5.Zheng, Y.; Su, M.; Zhou, S.; Zhang, T.; Wu, Y.; Xu, K.; Zhong,W. Endoplasmic Reticulum-Targeted Photodynamic Therapy Synergizeswith Rapamycin to Induce Autophagic Cancer Cell Death. ActaBiomaterialia 2026, 217, 586-599.
6.Jiao, Q.; Zhang, T.; Zhou, S.; Luo, X.; Pei, S.; Zheng, Y.; Xu,K.; Zhong, W. A Self-Assembling Chimeric Peptide Gear-Set with"Three-in-One" Function for Precision Photodynamic Therapy.Acta Biomaterialia 2025, 201, 559-573.
7.Zheng, Y.; Ma, X.; Zhou, S.; Lei, W.; Luo, X.; Zhou, L.; Xu, K.;Zhong, W. Alkaline Phosphatase and ATG4B Sequentially ActivatedFluorescent Probe for Cancer Cell-Specific Live Imaging of Autophagy.Analytical Chemistry 2025, 97, 8370-8377.
8.Pei, S.; Liu, Z.; Jiao, Q.; Jin, Q.; Luo, X.; Liu, Y.; Zhou, S.;Pang, S.; Wu, X.; Xu, K.; Zhong, W. Self-Reporting RatiometricAIEgen-Peptide Nanoprobes for Activatable Chemotherapy andNoninvasive Imaging of Therapeutic Outcomes. Journal of MedicinalChemistry 2025, 68(7), 7767-7779.
9.Chi, Y.; Zheng, Y.; Pan, X.; Huang, Y.; Kang, Y.; Zhong, W.; Xu,K. Enzyme-Mediated Fabrication of Nanocomposite HydrogelMicroneedles for Tunable Mechanical Strength and ControllableTransdermal Efficiency, Acta Biomaterialia 2024, 174,127-140.
10.Jiao, Q.; Zheng, Y.; Pei, S.; Luo, X.; Wu, X.; Xu, K.; Zhong,W. Cascade-Activated AIEgen-Peptide Probe for NoninvasivelyMonitoring Chymotrypsin-Like Activity of Proteasomes in Cancer Cells,Analytical Chemistry 2023, 95, 9097-9106.
代表性基金项目:
1.国家自然科学基金委员会,面上项目,82372114, 双通道NIR荧光探针标记的“肽中肽”纳米胶束用于多肽药物可视化精准递送的研究,2024-01-01 至2027-12-31, 49万元,在研,参与
2.国家自然科学基金委员会,面上项目,51973234, 酶促交联法制备透皮性能可控的水凝胶微针用于黑色素瘤联合治疗的研究,2020-01-01 至2023-12-31, 60万元,结题,主持