教育、工作背景：
2011-2015 中国药科大学 药学院 本科
2015-2018 中国药科大学 药学院 硕士 （导师，尤启冬教授）
2020-2024 中国药科大学 理学院 博士 （导师，张晓进教授）
2024-2026 中国药科大学 理学院 博士后 （合作导师，张晓进教授）
2026-现在 中国药科大学 化学学院 副研究员
简介：
伍悦，女，博士，副研究员，主要研究方向为靶向双加氧酶的创新药物研究。2024年博士毕业于中国药科大学药物化学专业。2024年至2026年在中国药科大学从事博士后研究工作（合作导师：张晓进教授），2026年晋升为副研究员。获博士后创新人才支持计划资助，主持国家自然科学基金青年基金1项、江苏省自然科学基金青年基金1项，中国博士后科学基金面上项目1项。近年以第一作者或通讯作者在Journalof the American Chemical Society、AngewandteChemie International Edition、Journalof Medicinal Chemistry等国际刊物发表论文12篇，作为项目骨干参与的FIH抑制剂候选新药项目实现技术成果转化。
研究方向：
药物化学、化学生物学
合作老师：
张晓进 教授
代表性文章：
1.Wu,Yue1;Li, Zhihong1;Kaur, Samanpreet1;Zhang, Zewei1;Yue, Jie; Tumber, Anthony; Zhang, Haoshu; Song, Zhe; Yang, Peiyao;Dong, Ying; Yang, Fulai; Li, Xiang; Schofield, Christopher*.; Zhang,Xiaojin*, Light-induced, lysine-targeting irreversible covalentinhibition of the human oxygen sensing hydroxylase factor inhibitingHIF (FIH). Journalof the American Chemical Society 2025,147(21), 17871-17879.
2.Wu,Yue;Chen, Yafen; Corner, Thomas P.; Nakashima, Yu; Salah, Eidarus; Li,Zhihong; Zhang, Linjian; Yang, Le; Tumber, Anthony; Sun, Zhuoli; Wen,Yukang; Zhong, Ailin; Yang, Fulai; Li, Xiang; Zhang, Zhihong;Schofield, Christopher*; Zhang, Xiaojin*, A small‐moleculeinhibitor of factor inhibiting HIF binding to a tyrosine‐flippocket for the treatment of obesity. AngewandteChemie International Edition 2024,63(40), e202410438.
3.Li, Zhihong1;Wu,Yue1;Zhen, Shuai; Su, Kaijun; Zhang, Linjian; Yang, Fulai; McDonough,Michael A.; Schofield, Christopher*; Zhang, Xiaojin*, In situinhibitor synthesis and screening by fluorescence polarization: anefficient approach for accelerating drug discovery. AngewandteChemie International Edition 2022,61(45), e202211510.
4.Wu,Yue1;Zhang, Linjian1;Li, Xiao; Cao, Ruiheng; Han, Shuang; Li, Shanrui; Aik, Wei Shen;Zhang, Haoshu; Yang, Peiyao; Bing, Tiande; Yang, Le; Yang, Fulai; Li,Xiang*; Zhang, Xiaojin*, Discovery of potent and selective THRβagonists based on an N-benzoylglycinescaffold for the treatment of metabolic disorders. Journalof Medicinal Chemistry 2026,69(15), 19279-19298.
5.Wu,Yue;Chen, Yafen; Cao, Ruiheng; Li, Xiang*; Zhang, Xiaojin*,Lysine-targeted covalent inhibitors: emerging warheads and expandingapplications in medicinal chemistry. Journalof Medicinal Chemistry 2026,69(11), 12744-12766.
6.Li, Ke1;Bing, Tiande1;Mo, Yikai; Wang, Wenxuan; Xing, Jihong; Yang, Le; Ao, Danni; Li,Zhihong; Yang, Fulai; Wu,Yue*;Zhang, Xiaojin*, A near-infrared photoactivatable, brain-penetrantprodrug of the prolyl hydroxylase inhibitor vadadustat forneuroprotection in ischemic stroke. Journalof Medicinal Chemistry 2026,69(10), 12702-12721.
7.Gao, Yinli1;Yang, Qingyun1;Liu, Simeng1;Liu, Jiaming1;Chen, Liwei; Bao, Xiaoqian; Zhang, Linjian; Yang, Le; Yang, Fulai;Li, Xiang; Wu,Yue*;Zhang, Xiaojin*, Discovery of 3-(arylamido)pyrazolopyridine HIF-2αagonists and a codrug strategy with prolyl hydroxylase inhibition forsynergistic treatment of renal anemia. Journalof Medicinal Chemistry 2025,68(23), 25569-25589.
8.Wu,Yue;Zhang, Zewei; Cai, Haiping; Zhang, Weiqing; Zhang, Linjian; Li,Zhihong; Yang, Le; Chen, Yafen; Corner, Thomas P.; Song, Zhe; Yue,Jie; Yang, Fulai; Li, Xiang; Schofield, Christopher*; Zhang,Xiaojin*, Discovery of ZG-2305, an orally bioavailable factorinhibiting HIF inhibitor for the treatment of obesity and fatty liverdisease. Journalof Medicinal Chemistry 2025,68(1), 212-235.
9.Wu,Yue1;Zhang, Linjian1;Sun, Zhuoli; Qiu, Xusheng; Chen, Yafen; Su, Kaijun; Yang, Le; Du,Zhongqiu; Dong, Ying; Yang, Fulai; Li, Xiang*; Zhang, Xiaojin*,Preferred conformation-guided discovery of potent and orally activeHIF prolyl hydroxylase 2 inhibitors for the treatment of anemia.Journalof Medicinal Chemistry 2023,66(13), 8545-8563.
10.Wu,Yue;Li, Zhihong; McDonough, Michael A.; Schofield, Christopher*; Zhang,Xiaojin*, Inhibition of the oxygen-sensing asparaginyl hydroxylasefactor inhibiting hypoxia-inducible factor: a potential hypoxiaresponse modulating strategy. Journalof Medicinal Chemistry 2021,64(11), 7189-7209.
代表性基金项目：
1.博士后创新人才支持计划，主持，结题
2.国家自然科学基金青年项目（C类），主持，在研
3.江苏省自然科学基金青年项目，主持，在研
4.中国博士后科学基金面上项目，主持，结题